Triethylene glycol monomethyl ether

Catalog Number

ACM112356-3

CAS

112-35-6

Structure

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

Synonyms

Methyltriglycol

IUPAC Name

2-[2-(2-methoxyethoxy)ethoxy]ethanol

Molecular Weight

164.20

Molecular Formula

C7H16O4

Canonical SMILES

COCCOCCOCCO

InChI

InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3

InChI Key

JLGLQAWTXXGVEM-UHFFFAOYSA-N

Boiling Point

122 °C at 10 mmHg (lit.)

Melting Point

-45°C (lit.)

Flash Point

118ºC

Purity

purum, ≥97.0% (GC)

Density

1.026 g/mL at 25 °C (lit.)

Solubility

6.09 M;In water, miscible;Soluble in water;Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.;Solubility in water: miscible

Appearance

Liquid

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

67.5

Covalently-Bonded Unit Count

1

EC Number

203-962-1

Exact Mass

164.10485899

Heavy Atom Count

11

Linear Formula

CH3(OCH2CH2)3OH

LogP

-0.34170

MDL Number

MFCD00002875

Monoisotopic Mass

164.10485899

PSA

47.92

REAXYS Number

1700198

Refractive Index

1.439

Topological Polar Surface Area

47.9 Ų

Viscosity

7 centistokes at 25 °C

WGK Germany

1

• Catalog Number: ACM112356-3
• CAS: 112-35-6
• Description: Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
• Synonyms: Methyltriglycol
• IUPAC Name: 2-[2-(2-methoxyethoxy)ethoxy]ethanol
• Molecular Weight: 164.20
• Molecular Formula: C7H16O4
• Canonical SMILES: COCCOCCOCCO
• InChI: InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3
• InChI Key: JLGLQAWTXXGVEM-UHFFFAOYSA-N
• Boiling Point: 122 °C at 10 mmHg (lit.)
• Melting Point: -45°C (lit.)
• Flash Point: 118ºC
• Purity: purum, ≥97.0% (GC)
• Density: 1.026 g/mL at 25 °C (lit.)
• Solubility: 6.09 M;In water, miscible;Soluble in water;Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.;Solubility in water: miscible
• Appearance: Liquid
• Application: Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
• Complexity: 67.5
• Covalently-Bonded Unit Count: 1
• EC Number: 203-962-1
• Exact Mass: 164.10485899
• Heavy Atom Count: 11
• Linear Formula: CH3(OCH2CH2)3OH
• LogP: -0.34170
• MDL Number: MFCD00002875
• Monoisotopic Mass: 164.10485899
• PSA: 47.92
• REAXYS Number: 1700198
• Refractive Index: 1.439
• Topological Polar Surface Area: 47.9 Ų
• Viscosity: 7 centistokes at 25 °C
• WGK Germany: 1